Softraid 5 1 torrent. PharmPK Discussion List Archive - PK2009039.html - 2009 PharmPK Discussion - AUCinf • On 8 May 2009 at 16:08:46, 'priyadeep.bhutani' (priyadeep.bhutani.-at.advinus.com) sent the message The following message was posted to: PharmPK Dear All: In serial sampling pharmacokinetic Study, if concentration at 24 hr (last sampling point) is found to be BLQ (below limit of quantification) and if we set BLQ as zero for data analysis, then Is AUCinf = AUC 0-24hr Or AUCinf = AUC 0-last + (last quantifiable concentration/k) So there is a confusion 'what is AUCinf in this case?' Please give your valuable suggestions Thanks in advance Priyadeep • On 8 May 2009 at 10:00:38, manish Issar (m.issar.at.gmail.com) sent the message Priyadeep First you need to be confident enough that the assay you have used is sensitive enough to capture at least 90% of the profile. If you analyze your data noncompartmentally using Winnonlin or any other validated software you will automatically get the AUCinf in the output. However, confidence on that parameter will depend on how close your estimation of the AUCinf is compared to the AUC0-24. The difference between the two parameters should be less than 10%, more conservatively 5%. If your difference between the AUC0-24 and AUCinf is greater than 10% your assay is not sensitive enough to capture atleast 90% of the profile hence you may have to revalidate your assay by increasing the sensitivity of the assay. Hope this helps.
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